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Chronic inflammation


Chronic inflammation

Homepage / Diseases / Chronical Inflammation

Inflammation is the body's natural defense reaction, which usually occurs briefly to fight pathogens. However, they can lead to illness if they become chronic. 


In cases of chronic inflammation, the body is unable to effectively defend itself against the constant release of inflammatory substances into organs and tissues. This results in inflammatory markers in the blood being permanently elevated and diseased cells in the inflamed area being gradually replaced by connective tissue. The inflamed tissue is broken down and slowly heals by forming scars. 


Chronic inflammation, depending on its location in the body, can permanently impair the normal function of affected tissues, even if treatment is provided. 

Chronical Inflammation

Causes of chronic inflammation

Chronic inflammation is now widespread and affects millions of people in developed countries and can be triggered by various causes. Here are some common causes of chronic inflammation:

Chronic Diseases

Causes of chronic inflammation



Long-term infections, such as bacterial, viral or parasitic infections, can cause chronic inflammation.


Autoimmune diseases

Autoimmune diseases such as rheumatoid arthritis, lupus, and Crohn's disease cause the immune system to attack healthy tissue, which can lead to chronic inflammation.



An unbalanced diet high in saturated fats, refined sugars, and processed foods can promote inflammation.



Overweight and obesity (obesity) are associated with chronic inflammation because fatty tissue can produce inflammatory substances.



Chronic stress can affect the immune system and contribute to inflammation.



Some people are at higher risk of chronic inflammation due to their genetic makeup.


Environmental factors

Environmental toxins, air pollution and certain chemicals can promote chronic inflammation.

Environmental factors as triggers

Chronic inflammation has been increasing worldwide for decades, and the causes are diverse. Environmental toxins, which are ubiquitous, especially in industrialized countries, play an important role.

New chemicals that are not beneficial to human health have found their way into our daily lifestyle. They can be found in household cleaning products, personal care products, cosmetics, textiles, indoor pollution, air pollution and, above all, in food.


Depending on the individual's ability to detoxify, these chemicals accumulate in different tissues and organs. This can lead to numerous health problems, including eye disease, heart problems, kidney and thyroid disease, and neurological disorders.

Clinical pictures and effects

Primary chronic inflammation

Primary chronic inflammation develop gradually and manifest themselves through slow or intermittent symptoms. The duration of an inflammatory attack often lasts longer than four weeks and complete healing is usually not possible. Examples of primary chronic inflammation are diseases such as type 1 diabetes Autoimmune diseases HowRheumatoid arthritis,multiple sclerosisorCrohn's disease, in which symptoms gradually progress.

A variety of diseases can be caused by chronic inflammation.

We differentiate between primary-chronic inflammation and secondary-chronic inflammation:

Symptoms of chronic inflammation

Chronic inflammation often begins gradually and symptoms often worsen over time. Chronic inflammation can cause a variety of symptoms that vary depending on the organ or tissue affected. Here are some common symptoms of chronic inflammation:


Chronic inflammation is often accompanied by persistent pain that may occur near the affected area.


Inflammation often leads to swelling and can cause tissue damage.


Inflamed areas may be red and warmer than the surrounding skin.


Joints can become stiff and less mobile when affected by inflammation.


Chronic inflammation can cause general tiredness and fatigue.


An increased body temperature can indicate inflammation, although this is not always the case.

weight loss

For some people, chronic inflammation can lead to unwanted weight loss.

Organ change

Depending on the area affected, chronic inflammation can lead to permanent organ damage.


The detailed medical history survey serves to collect information about symptoms, previous history and possible risk factors.

Physical examination

A thorough physical examination may reveal evidence of inflammation, such as swelling, redness, pain, or limited mobility.

Laboratory tests

In laboratory tests, doctors use special blood tests to determine whether there is inflammation in the body. Various markers are examined here:


  • C-reactive protein (CRP): This is where the biomarker CRP is determined in the blood, which is often used to assess inflammation in the body.


  • Erythrocyte sedimentation rate (ESR): The ESR measures how quickly red blood cells settle in the blood. This value is often used to detect inflammation or other diseases in the body.


  • Interleukins 1, 6 and 8: The values provide information about the presence of inflammatory messengers called interleukins, which are crucial in the body's immune response to infections and inflammation. 


  • Tumor necrosis factor alpha (TNF-α): This test examines TNF-α in the blood, a protein that is involved in inflammatory processes. 

Imaging procedures

Depending on whether a particular inflammation is suspected, an imaging test such as X-rays, CT scans or MRI scans may be required to examine the affected areas in more detail.


In some cases, a tissue biopsy may be necessary to make an accurate diagnosis. This involves taking a small sample of tissue and examining it under a microscope.


If there is inflammation in the digestive tract, an endoscopy can be performed to more accurately assess the condition of the mucous membrane.

Diagnostics for chronic diseases

Chronic inflammatory diseases often affect more than just one organ system. The diagnosis of chronic inflammation can be complex and depends on the type of inflammation and the patient's individual circumstances. 

At ELLANN® we work together with specialized doctors on an interdisciplinary basis, because thorough diagnostics are essential for optimal therapy planning.


Below are some common diagnostic procedures for chronic inflammation:

Treatment of chronic inflammation

The treatment of chronic inflammatory diseases can vary depending on the type of disease and individual health status. Here are some general approaches to treating such conditions:


Anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain and inflammation.


For autoimmune diseases, immunosuppressants or biologics may be prescribed to suppress the immune system and reduce inflammation.


Corticosteroids can be used in acute bursts to quickly combat inflammation.

Lifestyle changes

A healthy diet can help reduce inflammation. Antioxidant-rich foods such as fruits and vegetables are recommended.


Regular exercise can improve joint function and relieve pain.

Stress management techniques such as yoga or meditation can also be helpful.

physical therapy

Physical therapy can help improve mobility and reduce pain in affected areas.

Surgical interventions

In some cases, surgery may be necessary to remove damaged tissue or repair joints.In some cases, surgery may be necessary to remove damaged tissue or repair joints.

Alternative therapies

Some people seek alternative approaches such as acupuncture or homeopathy to relieve their symptoms. 


Cause therapy with INUSpherese® for chronic inflammatory diseases

With INUSpheresis®, we filter the blood to specifically remove substances that promote disease and cause inflammation, such as environmental toxins and misdirected autoimmune antibodies. At the same time, we demonstrably reduce the amount of inflammatory messengers such as CRP or TNF-a in the blood with every INUSpheresis®. 


With the help of INUSpherese® therapy, we address the causes and can thus have a positive influence on chronic inflammation. At ELLANN® we do not rely on medications that often have side effects to alleviate symptoms, but rather concentrate on specifically removing the disease-promoting factors from the body.



The method of therapeutic apharesis has been mentioned in over 21,000 scientific studies (PubMed, January 2021). The therapy concept of INUSpheresis® is also described in numerous publications. We have put together a selection of current articles and scientific studies for you: 

Effectiveness and study situation 

Alzheimer's dementia syndrome is a progressive brain disease that affects memory, thinking and behavior. Abnormal protein deposits in the brain are characteristic of this disease.

Alzheimer dementia syndrome

Lyme disease (Lyme disease)

Lyme disease is a tick-borne infectious disease caused by the bacterium Borrelia burgdorferi. It can cause a variety of symptoms, including skin rash, joint pain and neurological problems.

Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome is a condition that causes persistent and extreme fatigue that is not relieved by rest or sleep. It may be accompanied by other symptoms such as muscle pain, headaches and problems concentrating.

Chronic hepatitis C

Chronic hepatitis C is a liver disease caused by the hepatitis C virus. It can take years or even decades for symptoms to appear. When they occur, they can cause liver problems such as inflammation and scarring, which can lead to cirrhosis and liver cancer.

coming soon

Ulcerative colitis

Ulcerative colitis is a chronic inflammatory disease of the intestine in which the natural defense mechanisms of the intestine are compromised. Immune system is disturbed. This can lead to inflammation and ulceration of the colon and manifest itself in symptoms such as diarrhea, abdominal pain and weight loss.

Crohn's disease

Crohn's disease is another chronic inflammatory bowel disease in which there is a barrier disorder in the intestine, which contributes to the immune system's reaction and thus inflammation. This can lead to severe abdominal pain, diarrhea, weight loss, and inflammation in various parts of the digestive tract.

Find out more about how it works and the treatment process at INUSpherese®.

Therapy indications

The positive benefits of INUSpheresis® have already been proven in numerous clinical pictures. We at ELLANN®  treat as part of our holistic therapy approachAutoimmune diseases,Environmental diseases,Metabolic diseases including the following chronic inflammatory diseases: 

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  • ⎯⎯•  Allergies

    ⎯⎯•  Lyme disease

    ⎯⎯•  Chronic fatigue syndrome (CFS)

    ⎯⎯•  Chronic hepatitis C

    ⎯⎯•  Hashimoto

    ⎯⎯•  Hyperlipidemia

    ⎯⎯•  Crohn's disease

    ⎯⎯•  multiple sclerosis

    ⎯⎯•  Multiple Chemical Hyper-

                sensitivity syndrome (MCS)

    ⎯⎯•  Parkinson's

    ⎯⎯•  Post-COVID syndrome

    ⎯⎯•  Post-vac syndrome

    ⎯⎯•  Rheumatism (chronic inflammatory)

    ⎯⎯•  Heavy metal poisoning

    ⎯⎯•  and more

  • INUSpheresis® was developed to remove a variety of disease-promoting substances and toxic substances from the blood. These include environmental toxins, heavy metals, allergens, metabolic products, inflammatory messengers, infection toxins and harmful proteins. Specially developed filters make it possible to specifically filter out these pollutants while preserving healthy components of the blood. INUSpherese® does not affect your vaccination protection because antibodies and immune cells that are responsible for your vaccination protection are preserved. This makes INUSpheresis® an extremely effective method for cleaning blood plasma and supporting general well-being and health.

  • INUSpheresis® is not a conventional blood wash or plasma exchange method. It is also not dialysis, in which urinary substances are filtered out. INUSpheresis® is characterized by the targeted removal of harmful substances, while essential and healthy components of your blood remain untouched. This includes vital electrolytes, proteins, nutrients, blood cells and antibodies. The use of specially developed filters ensures that only pathogenic contamination is removed during the treatment. This makes the treatment particularly gentle and generally very well tolerated. 

  • The number of INUSpherese® treatments required depends on your individual health status and health goals. A basic cycle of two treatments within 48 hours is recommended. For more intensive needs, such as extensive heavy metal elimination or complex clinical pictures, a third and even fourth treatment session every 6 to 7 weeks can make sense. Your personal treatment plan will be drawn up by our doctors after a detailed consultation.

  • An INUSpherese® therapy, which consists of two treatments, accompanying infusion concepts and a preparatory medical consultation, is usually priced between €5,400 and €5,700. This cost information is intended to serve as a rough guide, as the exact investment can vary depending on your individual health condition and any additional therapy options. As part of the therapy planning, you will receive detailed advice and a detailed cost overview that is individually tailored to your health goals.

Frequently asked Questions

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