ALZHEIMER DEMENTIA SYNDROME
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Alzheimer Dementia Syndrome
Alzheimer's dementia syndrome, colloquially known as Alzheimer's for short, is a type of dementia that usually affects people aged 65 and over. The slowly progressive death of nerve cells in the brain due to protein deposits leads to memory loss, confusion and disorientation.
Alzheimer Dementia Syndrome
Causes of Alzheimer dementia syndrome
Causes
The exact causes of accelerated brain deterioration in Alzheimer's dementia are not yet fully understood. Both genetic and environmental factors are thought to play a role. A family predisposition can increase the risk of Alzheimer's disease. Age and hereditary factors are believed to have a major influence on the likelihood of developing Alzheimer's dementia.
Deposition of plaques in the brain
Protein deposits in the brain play an important role in the development of Alzheimer's dementia. Two types of proteins have been identified, called beta-amyloid and tau. In Alzheimer's patients, these proteins are deposited in the brain in the form of plaques and fibrils. Normally these proteins are broken down. In Alzheimer's patients, this clean-up process in the brain no longer works, which inhibits the energy and oxygen supply to the brain and the nerve cells ultimately die.
Genetic predisposition
5-15% of people who develop Alzheimer's disease have a familial history. In half of these cases, Alzheimer's occurs early, before the age of 65, and is usually caused by certain changes in the genetic makeup, more specifically in the gene called ApoE (Apo-Lipoprotein E).
Risk factors that promote the disease
⎯⎯• High blood pressure
⎯⎯• Diabetes
⎯⎯• Lipid metabolism disorders
⎯⎯• Excessive alcohol consumption
Other factors that can increase the risk of Alzheimer's dementia include advanced age, female gender and certain lifestyle factors such as unhealthy diet, lack of exercise and social isolation.
Environmental influences
Environmental influences are often discussed as potential causes of Alzheimer's. There are some environmental factors that are associated with an increased risk of developing Alzheimer's:
⎯⎯•Air pollution
Studies suggest that long-term exposure to air pollution, particularly particulate matter, may increase the risk of Alzheimer's disease.
⎯⎯•Harmful chemicals
Exposure to certain harmful chemicals, such as lead and mercury, has also been linked to an increased risk of Alzheimer's disease.
⎯⎯•Pesticides and herbicides
Some research suggests that exposure to pesticides and herbicides may increase the risk of Alzheimer's disease.
However, it is important to note that Alzheimer's is a complex disease with many factors at play. Environmental influences alone cannot reliably explain the development of Alzheimer's disease. Research in this area is still ongoing, and further studies are needed to understand the precise links between environmental factors and Alzheimer's disease.
Symptoms of Alzheimer's dementia syndrome
Symptoms of Alzheimer's disease usually develop gradually and worsen over time. The main difference from other dementias is that Alzheimer's usually affects short-term memory rather than other mental abilities. This manifests itself, for example, in repetitive questions, frequently misplacing objects, forgetting appointments or assigning names to familiar faces.
Alzheimer's disease is otherwise associated with many similar symptoms to other dementias, such as:
⎯⎯• Memory loss
⎯⎯• Problems with language
⎯⎯• Personality changes
⎯⎯• Disorientation
⎯⎯• Problems coping with tasks in daily life
⎯⎯• fears
⎯⎯• depressions
⎯⎯• sleep disorders
⎯⎯• Illusions
⎯⎯• Aggressive or inappropriate behavior
Not every person with Alzheimer's has all of these symptoms. The course of the disease can vary from person to person.
Treatment options for Alzheimer's dementia syndrome
Treatment primarily focuses on relieving symptoms and improving patients' quality of life. There is currently no cure for Alzheimer's dementia.
Treatment usually includes a combination of drug and non-drug therapy.
Medication
⎯⎯• Cholinesterase inhibitors are often prescribed to relieve cognitive symptoms
⎯⎯• Memantine can be used in combination with
Cholinesterase inhibitors may be prescribed to relieve neurological symptoms
⎯⎯• Anti-dementia medications can be used to improve memory and slow disease progression
Non-drug therapy
⎯⎯• Occupational therapy
⎯⎯• Music therapy
⎯⎯• Physiotherapy
⎯⎯• Social activities
⎯⎯• Memory training
Diet and lifestyle
A balanced diet, regular physical activity and mental stimulation can help slow the progression of the disease.
In addition, the support of relatives plays an important role in the treatment of Alzheimer's dementia. Building a safe and supportive environment, providing information and training, and social inclusion can help improve patient well-being.
It is important to note that Alzheimer's dementia is a progressive disease and that treatment is aimed at relieving symptoms and slowing the progression of the disease rather than curing it.
INUSpheresis®
INUSpherese® for Alzheimer's dementia syndrome
INUSpheresis® is a therapeutic method used in the treatment of Alzheimer's and other neurological diseases. It is a form of blood plasma purification that aims to rid the body of harmful substances such as toxins, inflammatory mediators and pathogenic proteins.
For many neurodegenerative diseases, such as Alzheimer's or Parkinson's, brain detoxification is indicated as part of the treatment. In addition to the protein accumulations already mentioned, it is often the light and heavy metal contamination that has accumulated in the brain and can no longer be effectively detoxified. This is where INUSpheresis® comes into play. It is a special form of blood washing that aims to specifically rid the body of harmful substances such as toxins, heavy and light metal contamination, fat accumulation in the blood, inflammatory mediators and pathogenic proteins.
INUSpheresis® aims to reduce existing inflammation and support the brain in detoxification. However, it is important to emphasize that INUSpherese® therapy is not a cure for Alzheimer's, but can lead to an improvement in the symptoms and progression of the disease. Treatment results may vary depending on individual cases.
We will use INUSpheresis® for various chronic diseases, including autoimmune diseases, chronic inflammation, environmental stresses and other health problems such as long-COVID.
Current therapeutic approaches to treating Alzheimer's disease remain disappointing, leaving an urgent need for effective treatments. In this study, we provide an overview of the emerging role of "metabolic inflammation" and stress as a key factor in the pathogenesis of Alzheimer's disease and propose a new concept to correct metabolic inflammation, increase resistance, and potentially slow or stop it Stopping the progression of the neurodegenerative process. Based on recent findings and the observations of an initial pilot test in 2020, we assume that extracorporeal apheresis can be used to treat Alzheimer's disease. Apolipoprotein E, lipoprotein(a), oxidized LDL (low density lipoprotein) and large LDL particles, as well as other pro-inflammatory lipids and stress hormones such as cortisol, are known to be key factors in the formation of amyloid plaques and the exacerbation of Alzheimer's disease. After extracorporeal double-membrane apheresis in patients with Alzheimer's disease, there was a significant reduction in proinflammatory lipids, circulating cytokines, immune complexes, proinflammatory metals, and toxic chaperones.
Study Situation
⎯⎯• Allergies
⎯⎯• Lyme disease
⎯⎯• Chronic fatigue syndrome (CFS)
⎯⎯• Chronic hepatitis C
⎯⎯• Hashimoto
⎯⎯• Hyperlipidemia
⎯⎯• Crohn's disease
⎯⎯• multiple sclerosis
⎯⎯• Multiple Chemical Hyper-
sensitivity syndrome (MCS)
⎯⎯• Parkinson's
⎯⎯• Post-COVID syndrome
⎯⎯• Post-vac syndrome
⎯⎯• Rheumatism (chronic inflammatory)
⎯⎯• Heavy metal poisoning
⎯⎯• and more
INUSpheresis® was developed to remove a variety of disease-promoting substances and toxic substances from the blood. These include environmental toxins, heavy metals, allergens, metabolic products, inflammatory messengers, infection toxins and harmful proteins. Specially developed filters make it possible to specifically filter out these pollutants while preserving healthy components of the blood. INUSpherese® does not affect your vaccination protection because antibodies and immune cells that are responsible for your vaccination protection are preserved. This makes INUSpheresis® an extremely effective method for cleaning blood plasma and supporting general well-being and health.
INUSpheresis® is not a conventional blood wash or plasma exchange method. It is also not dialysis, in which urinary substances are filtered out. INUSpheresis® is characterized by the targeted removal of harmful substances, while essential and healthy components of your blood remain untouched. This includes vital electrolytes, proteins, nutrients, blood cells and antibodies. The use of specially developed filters ensures that only pathogenic contamination is removed during the treatment. This makes the treatment particularly gentle and generally very well tolerated.
The number of INUSpherese® treatments required depends on your individual health status and health goals. A basic cycle of two treatments within 48 hours is recommended. For more intensive needs, such as extensive heavy metal elimination or complex clinical pictures, a third and even fourth treatment session every 6 to 7 weeks can make sense. Your personal treatment plan will be drawn up by our doctors after a detailed consultation.
An INUSpherese® therapy, which consists of two treatments, accompanying infusion concepts and a preparatory medical consultation, is usually priced between €5,400 and €5,700. This cost information is intended to serve as a rough guide, as the exact investment can vary depending on your individual health condition and any additional therapy options. As part of the therapy planning, you will receive detailed advice and a detailed cost overview that is individually tailored to your health goals.